Systemic lupus erythematosus (SLE) is an autoimmune disorder where the immune system attacks its own tissues, such as the joints, kidneys, heart, lungs, blood vessels, and brain. Lupus nephritis (LN) is a manifestation of SLE causing inflammation in the kidneys affecting up to one third of those with SLE. This inflammation results in poorly functioning kidneys. When the kidneys are not functioning well, they cannot properly remove waste or control the amount of fluid in the body. LN can lead to permanent kidney damage and potentially end stage renal disease (ESRD), which may require dialysis or kidney transplant. Presently, there is no cure for SLE or LN.