Hereditary Transthyretin Amyloidosis (hATTR) is a rare condition caused by one or more changes in your genes for a protein called Transthyretin (TTR). These changes lead to a build-up of abnormal proteins called amyloid in different parts of the body including tissues and organs. As the disease progresses it typically presents as heart and/or nerve issues otherwise called cardiomyopathy (CM) or polyneuropathy (PN). The accumulation of this protein in tissues can also lead to additional symptoms like carpal tunnel, movement issues, nerve pain, vision changes, and heart failure. Patients that experience hATTR with polyneuropathy can eventually have trouble with movements of the arms or legs while patients with cardiomyopathy can experience fatigue, abnormal heart rhythms and shortness of breath. Since this disease causes a progressive worsening in symptoms as well as health-related quality of life, early detection and treatment is important otherwise permanent complications can occur. It is estimated that about 1 in every 100,000 people in the United States have the condition, with African American males being affected the most. Symptoms typically start after the age of 50 but can begin anywhere between the ages 20 and 80.